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pentobarbital decreases results of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of CYP3A4 inducers may lessen sufentanil concentrations and efficacy, possibly precipitating withdrawal syndrome in individuals which have developed Bodily dependence to sufentanil. Discontinuatio

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